Vandetanib-d<sub>3</sub> N-Oxide





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SL-372

Vandetanib-d3 N-Oxide, 97% (CP)

 
Isotopic Purity : 99 atom % D
MDL No. : MFCD28343978
Related CAS No. : [1797030-22-8] of the unlabelled compound
Synonym (s) : 4-(((4-((4-Bromo-2-fluorophenyl)amino)-6-methoxy-d3-quinazolin-7-yl)oxy)methyl)-1-methylpiperidine 1-oxide
Price and Availability
Pack SizePrice in USDQuantityAvailabilityShipping Status
5MG1680.00Back Order Estimated to Ship on 09.01.2017
10MG2680.00Back Order Estimated to Ship on 09.01.2017
Chemical Properties
Mol. Formula : C22H21D3BrFN4O3Appearance : Solid
Mol. Weight : 494.37Melting Point : Not available
     For Laboratory research use only, not for drug, household or other uses.
Applications : Vandetanib N-Oxide-d3 is the deuterium labelled analogue of second major metabolite of Vandetanib N-Oxide, formed during the metabolism of vandetanib via flavin-containing monooxygenase (FMO) polymorphisms FMO1 and FMO3. Exposure to vandetanib N-oxide was very low compared with that of vandetanib and increased exposure to vandetanib N-oxide led to severe hepatic impairment.
Reference : GiangThy N T. Am. J. Health. Syst. Pharm. 70(10), 849, 2013.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.
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