1-((4-Chlorophenyl)(phenyl)methyl)-4-nitrosopiperazine

SL-8072

1-((4-Chlorophenyl)(phenyl)methyl)-4-nitrosopiperazine, >98%

CAS No. : [2005-04-1]

Synonyms : N-Nitroso hydroxyzine EP impurity A; Cetirizine intermediate nitroso impurity

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Applications : This is a nitrosamine of Cetirizine, which is a second-generation antihistamine and the carboxylated metabolite of hydroxyzine. Cetirizine is a specific, orally active and long-acting histamine H1-receptor antagonist.

References : Caroline M. S. et al.: Drugs 46(6), 1055-1080, 1993; Shih M. Y. et al.: Allergy Asthma Proc., 29(5), 480-5, 2008; Shimizu T. et al.: Clin Exp Allergy 34(1), 103-9, 2004.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.