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1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole dihydrochloride

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SL-4964

1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole dihydrochloride, >98%

CAS No. : [212248-62-9]

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Chemical Properites
Mol. Formula :
C9H11N5 . 2HCl
Mol. Weight :
262.14
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of Rizatriptan and related analogs. Rizatriptan is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.

References : Williamson D. J. et al.: Br. J. Pharmacol, 133(7), 1029-1034, 2001; Williamson D. J. et al.: Eur J. Pharmacol, 328(1), 61-64, 1997; Yao G. et al.: Neural Regen Res, 7(2), 131-135, 2012; Wang X. et al.: Brain Res, 1367, 340-346, 2011; Dong Z. et al.: Brain Res, 1368, 151-158, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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