1'-Benzyl-[1,4'-bipiperidine]-4'-carboxamide

SL-9783

1'-Benzyl-[1,4'-bipiperidine]-4'-carboxamide, >98%

CAS No. : [1762-50-1]

IUPAC Name : 1-Benzyl-4-carbamoyl-4-piperidinopiperidine

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Applications : This is an advanced key intermediate in the preparation of Pipamperone, which is a butyrophenone derivative that serves as a high-affinity antagonist for the 5-HT2A receptor (pKi=8.2) and D₄ receptor (pKi=8.0), while exhibiting low-affinity antagonism at the D₂ receptor (pKi=6.7). By modulating neurotransmitter activity, pipamperone demonstrates antipsychotic effects. Pipamperone is utilised in research focused on mental health conditions, including autism-related behavioural disorders and Alzheimer's disease.

References : Oekelen D. V. et al.: Eur. J. Pharmacol., 425(1), 21-32, 2001; Petrosino B. et al.: European Psychiatry 33(S1), S549-S549, 2016; Kamp D. et al.: Ther Adv Psychopharmacol., 6(1), 55-57, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.