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1-epi-Regadenoson

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1-epi-Regadenoson, >98%

CAS No. : [2015222-31-6]

Synonyms : Regadenoson impurity C

IUPAC Name : 1-(6-Amino-9-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide

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Chemical Properites
Mol. Formula :
C15H18N8O5
Mol. Weight :
390.36
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Regadenoson, which is a selective A2A adenosine receptor agonist and vasodilator that enhances coronary blood flow and is utilized in myocardial perfusion imaging studies. Additionally, Regadenoson increases the permeability of the blood-brain barrier (BBB) in rodent models, which may facilitate the investigation of improved delivery of agents to the human central nervous system.

References : Trochu J. N. et al.: J. Cardiovasc Pharmacol., 41(1), 132-9, 2003; Jackson S. et al.: T. J. Neurooncol., 126(3), 433-9, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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