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15-keto-Latanoprost

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SL-10803

15-keto-Latanoprost, >98%

CAS No. : [135646-98-9]

IUPAC Name : Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl)hept-5-enoate

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5MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C26H38O5
Mol. Weight :
430.59
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a minor metabolite of Latanoprost, which is a prostaglandin F2α analog and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to Latanoprost acid. Latanoprost acid is an F-prostaglandin (FP) receptor agonist and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea.

References : Pauly A. et al.: Invest Ophthalmol Vis Sci., 53(13), 8172-80, 2012; Zheng J. et al.: Cell Mol Neurobiol., 31(4), 597-604, 2011; Tsai S. et al.: Vet Ophthalmol., 16(5), 370-6, 2013; Ooi Y. H. et al.: Invest Ophthalmol Vis Sci., 50(11), 5259-65, 2009; B'Ann True G. et al.: J. Ocul Pharmacol Ther., 25(1), 1-8, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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