(1R, 2R)-Ifenprodil

SI-6261

(1R, 2R)-Ifenprodil, >98% (HPLC)

CAS No. : [74991-36-9]

IUPAC Name : 4-((1R,2R)-2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol

Price And Availability
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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : (1R,2R)-Ifenprodil is the most active stereoisomer of Ifenprodil, showing highest GluN2B affinity (K_i = 5.8 nM) and strong ion‑channel inhibition (IC₅₀ = 223 nM). Stereochemical studies reveal that the (1R)-configuration is essential for elevated inhibitory activity. (1R,2R)-Ifenprodil displays high selectivity for GluN2B‑NMDA receptors over adrenergic, serotonergic, and σ₁ receptors, making it the preferred stereoisomer for mechanistic and pharmacological studies.

References : Bechthold E. et al.: J. Med. Chem., 64(2), 1170-1179, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.