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2',3',5'-Tri-O-benzoyl-2'-C-methyluridine

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2',3',5'-Tri-O-benzoyl-2'-C-methyluridine, >98%

CAS No. : [23643-36-9]

Synonyms : Uridine, 2'-C-methyl-, 2',3',5'-tribenzoate

IUPAC Name : (2R,3R,4R,5R)-5-((Benzoyloxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate

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25MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
50MGRequest A Quote
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250MGRequest A Quote
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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C31H26N2O9
Mol. Weight :
570.55
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of Sofosbuvir, which is a novel nucleotide NS5B polymerase inhibitor. Sofosbuvir has showed promising therapeutic activity against hepatitis C virus.

References : Gentile I. et al.: Curr. Med. Chem., 20(30), 3733, 2013; Murakami E. et al.: J. Biol Chem., 285(45), 34337-47, 2010; Lam A. M. et al.: Antimicrob Agents Chemother., 56(6), 3359-68, 2012; Sofia M. J. et al.: J Med Chem., 53(19), 7202-18, 2010; Zhang X, et al.: Eur. J. Med Chem.,143, 1053-1065, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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