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2,3-Desisopropylidene topiramate

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SL-6229

2,3-Desisopropylidene topiramate, >98%

CAS No. : [851957-35-2]

Synonyms : 4,5-O-(1-Methylethylidene)-β-D-fructopyranose 1-sulfamate

IUPAC Name : ((3aR,6R,7S,7aS)-6,7-Dihydroxy-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl)methyl sulfamate

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Chemical Properites
Mol. Formula :
C9H17NO8S
Mol. Weight :
299.29
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a metabolite of Topiramate, which is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.

References : Taverna S. et al.: J. Pharmacol Exp Ther., 288(3), 960-968, 1999; Gryder D. S. et al.: J. Neurosci., 23(18), 7069-7074, 2003; Yang Y. et al.: Brain Res., 804(2), 169-176, 1998; Kaminski R. M. et al.: Neuropharmacology 46(8), 1097-1104, 2004; Koh S. et al.: Ann Neurol., 50(3), 366-372, 2001; Nakamura J. et al. Eur J. Pharmacol., 254(1-2), 83-89, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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