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2-((3bS,4aR)-5,5-Difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-2H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-2-yl)acetic acid

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2-((3bS,4aR)-5,5-Difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-2H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-2-yl)acetic acid, >98%

CAS No. : [1620056-83-8]

Synonyms : Lenacapavir pyrazole acetic acid impurity

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Chemical Properites
Mol. Formula :
C10H7F5N2O2
Mol. Weight :
282.17
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This compound is identified as an impurity associated with Lenacapavir. It is a unique, long-acting HIV-1 capsid inhibitor approved for treating multi-drug-resistant HIV and is highly effective as a twice-yearly injection for HIV prevention (PrEP).

References : Singh K. et al.: Front Microbiol., 10, 1227, 2019; John O. L. et al.: Nature, 584(7822), 614-61, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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