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2-Hydroxy estrone

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2-Hydroxy estrone, >98%

CAS No. : [362-06-1]

Synonyms : Catechol estrone; 2-OHE1

IUPAC Name : (8R,9S,13S,14S)-2,3-Dihydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one

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Chemical Properites
Mol. Formula :
C18H22O3
Mol. Weight :
286.37
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : 2-Hydroxy estrone is a major, weakly estrogenic, and non-proliferative metabolite of estrone, often referred to as a "good estrogen". It acts as an antiestrogen, protecting against estrogen-dependent cancers by competing with stronger estrogens (e.g. 16-Hydroxy estrone) and inhibiting cell proliferation, particularly in breast cancer models.

References : Bradlow H. L. et al.: J. Endocrinol., 150 Suppl, S259-65, 1996; Schneider J. et al.: J. Biol Chem., 259(8), 4840-4845, 1984; Nakagomi M. et al.: Chem Res Toxicol. 13(12), 1208-13, 2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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