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2-O-Demethylcolchicine

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SL-6531

2-O-Demethylcolchicine, >98%

CAS No. : [102491-80-5]

Synonyms : 2-Demethylcolchicine

IUPAC Name : (S)-N-(2-Hydroxy-1,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

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Chemical Properites
Mol. Formula :
C21H23NO6
Mol. Weight :
385.42
Appearance :
Pale yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : 2-O-Demethylcolchicine is a metabolite and an impurity of Colchicine, which is a microtubule polymerization inhibitor, used to treat gout and behcet's disease. Also it has shown anti-tumor activity.

References : Bonfoco E. et al.: Exp Cell Res., 218(1), 189-200,1995; Hastie S. B. Pharmacol Ther., 51(3), 377-401,1991; Otani K. et al.: Sci Rep., 6, 32587, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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