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2-Thiocyanato-4-(trifluoromethoxy)aniline

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2-Thiocyanato-4-(trifluoromethoxy)aniline, >98%

CAS No. : [1391054-04-8]

Synonyms : Riluzole impurity A; Riluzole impurity 1

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Chemical Properites
Mol. Formula :
C8H5F3N2OS
Mol. Weight :
234.2
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the synthesis of Riluzole and related analogs. Riluzole is an anticonvulsant that acts as a use-dependent Na+ channel blocker and inhibits GABA uptake with an IC50 of 43 μM.

References : He Y. et al.: Neuropharmacology, 42(2), 199-209, 2002; Thompson J. M. et al.: Mol Pain, 11, 51, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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