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(3-(4-Acetyl-3,3-dimethyl-2-oxopiperazin-1-yl)-4-cyanophenyl)boronic acid pinacol ester

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SI-1388

(3-(4-Acetyl-3,3-dimethyl-2-oxopiperazin-1-yl)-4-cyanophenyl)boronic acid pinacol ester, 97%

CAS No. : [1983205-56-6]

IUPAC Name : 2-(4-Acetyl-3,3-dimethyl-2-oxopiperazin-1-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

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Chemical Properites
Mol. Formula :
C21H28BN3O4
Mol. Weight :
397.28
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of SI-1377 and related analogs, which is a phosphatidylinositol 3‑kinase δ (PI3Kδ) inhibitor for the treatment of immunological disorders.

References : Liu Q. et al.: J. Med. Chem., 60(12), 5193-5208, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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