3'-Amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

SL-10534

3'-Amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, >98%

CAS No. : [376592-93-7]

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Applications : This is an advanced key intermediate in the synthesis of Eltrombopag and related analogs. Eltrombopag is a thrombopoietin-receptor agonist used to treat low blood platelet counts with chronic immune thrombocytopenia.

References : Erickson-Miller C. L. et al.: Stem Cells 27(2), 424-430, 2009; Erickson-Miller C. L. et al.: Exp Hematol. 33(1), 85-93, 2005; McHutchison J. G. et al.: N. Engl. J. Med., 357(22), 2227-2236, 2007; Jenkins J. M. et al.: Blood 109(11), 4739-4741, 2007; Saleh M. N. et al.: Blood 121(3), 537-545, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.