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3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

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SL-6480

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde, >98%

CAS No. : [162401-78-7]

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Chemical Properites
Mol. Formula :
C12H12F2O3
Mol. Weight :
242.22
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of Roflumilast related analogs, which is a selective PDE4 inhibitor, used in the treatment of severe chronic obstructive pulmonary disease (COPD).

References : Hatzelmann A. et al.: Pulm Pharmacol Ther., 23(4), 235-256, 2010; Rabe K. F. Br. J. Pharmacol., 163(1), 53-67, 2011; Hatzelmann A. et al.: J. Pharmacol Exp Ther., 297(1), 267-279, 2001; Richmond B. W. et al.: Nat. Commun. 7, 11240, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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