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3-Dechloro-2-chloro roflumilast

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SL-6475

3-Dechloro-2-chloro roflumilast, >98%

CAS No. : [2204417-23-0]

IUPAC Name : 3-(Cyclopropylmethoxy)-N-(2,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

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Chemical Properites
Mol. Formula :
C17H14Cl2F2N2O3
Mol. Weight :
403.21
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Roflumilast, which is a selective phosphodiesterase-4 (PDE-4) inhibitor, used in the treatment of severe chronic obstructive pulmonary disease (COPD).

References : Hatzelmann A. et al.: Pulm Pharmacol Ther., 23(4), 235-256, 2010; Rabe K. F. Br. J. Pharmacol., 163(1), 53-67, 2011; Hatzelmann A. et al.: J. Pharmacol Exp Ther., 297(1), 267-279, 2001; Richmond B. W. et al.: Nat. Commun. 7, 11240, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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