3-(Methylamino-d3)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonitrile

SL-3298

3-(Methylamino-d3)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonitrile, >98% (CP)

Isotopic Purity : 99 atom % D

CAS No. : [1794979-58-0]

IUPAC Name : 2,3,4,9-Tetrahydro-3-(methylamino-d3)-1H-carbazole-6-carbonitrile

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Applications : This is an advanced deuterium labelled key intermediate in the preparation of labelled Frovatriptan and related analogs. Frovatriptan is a serotonin 5-HT1B/1D receptor agonist. A triptan drug for the treatment of migraine headaches and for short term prevention of menstrual migraine.

References : Parsons A. A. et al.: J. Cardiovasc. Pharmacol., 30, 136, 1997; Siow, C. H. et al.: Cephalalgia, 24, 1045, 2004; Poolsup N. et al.: J. Clin. Pharm. Ther., 30, 521, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.