3-Methylthienyl-carbonyl-JNJ-7706621

SI-7827

3-Methylthienyl-carbonyl-JNJ-7706621, >98% (HPLC)

CAS No. : [443798-09-2]

IUPAC Name : 4-((5-Amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide

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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : 3‑Methylthienyl‑carbonyl‑JNJ‑7706621 potently inhibits CDK1/Cyclin B (IC₅₀ = 6.4 nM) and CDK2/Cyclin A (IC₅₀ = 2 nM), while also targeting GSK‑3 with sub‑micromolar potency (IC₅₀= 0.041 µM). It exhibits moderate inhibitory activity against CDK4, VEGFR2, and FGFR2. This multi‑kinase profile makes it a valuable tool for investigating CDK‑driven cell‑cycle regulation and cancer‑associated signaling pathways.

References : Lin R. et al. J. Med. Chem., 48(13), 4208-11, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.