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(3R,4S)-Tofacitinib

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(3R,4S)-Tofacitinib, >98%

CAS No. : [1092578-46-5]

IUPAC Name : 3-((3R,4S)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

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Chemical Properites
Mol. Formula :
C16H20N6O
Mol. Weight :
312.38
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : (3R,4S)-Tofacitinib is a diastereomer of Tofacitinib, which is a potent, specific, orally active JAK3 inhibitor. Tofacitinib is used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. This is also a COVID-19 related research chemical.

References : Changelian P. S. et al.: Science 302(5646), 875-888, 2003; Jiang J. K. et al.: J. Med. Chem., 51(24), 8012-8018, 2008; Kudlacz E. et al.: Am. J. Transplant., 4(1) 51-57, 2004.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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