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4-(6-Hydroxybenzo[b]thiophen-2-yl)benzene-1,2-diol

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4-(6-Hydroxybenzo[b]thiophen-2-yl)benzene-1,2-diol, >98%

CAS No. : [414861-41-9]

Synonyms : Raloxifene impurity 18

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Chemical Properites
Mol. Formula :
C14H10O3S
Mol. Weight :
258.29
Appearance :
Grey solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity in the preparation of Raloxifene, which is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.

References : Obach R. S. et al.: Drug Metab Dispos., 32(1), 89-97, 2004; Yang N. N. et al.: Endocrinology., 137(5), 2075-2084, 1996; Black L. J. et al.: J. Clin Invest., 93(1), 63-69, 1994; Evans G. et al.: Endocrinology, 134(5), 2283-2288, 1994; Sato M. et al.: FASEB J, 10(8), 905-912, 1996.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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