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4-alpha-Hydroxy cholesterol

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4-alpha-Hydroxy cholesterol, >98%

CAS No. : [34310-86-6]

Synonyms : 4α-Hydroxy cholesterol

IUPAC Name : (3S,4S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,4-diol

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Chemical Properites
Mol. Formula :
C27H46O2
Mol. Weight :
402.66
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an oxysterol, or oxidized derivative of Cholesterol, which is the primary sterol found in mammals, comprising 20-25% of the structural components of the plasma membrane. Plasma membranes allow water to pass through easily but are comparatively resistant to ions and protons. Cholesterol influences the fluidity and permeability properties of the membrane and affects the functions of transporters and signaling proteins. Additionally, cholesterol acts as an endogenous agonist for estrogen-related receptor α (ERRα).

References : Casaburi I. et al.: Front Endocrinol (Lausanne) 9, 525, 2018; Dietschy J. M. et al.: J. Lipid Res., 45(8), 1375-97, 2004; Puskás L. G. et al.: FEBS Lett., 562(1-3), 99-104, 2004; Onody A. et al.: Cardiovasc Res., 58(3), 663-70, 2003; Baumer Y. et al.: Nat Commun., 8(1), 1129, 2017; Finking G. et al.: Atherosclerosis. 135(1), 1-7, 1997; Fan J. et al.: Methods Mol Biol., 2419, 413-431, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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