4-(Difluoromethoxy)-3-hydroxybenzoic acid

SL-6481

4-(Difluoromethoxy)-3-hydroxybenzoic acid, >98%

CAS No. : [913985-07-6]

MDL No. : MFCD24497448

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
1G	85.00		Back Order	Estimated to ship on 04 October 2026
5G	345.00		Back Order	Estimated to ship on 04 October 2026
10G	645.00		Back Order	Estimated to ship on 04 October 2026
25G	1245.00		Back Order	Estimated to ship on 04 October 2026

Applications : This is an advanced key intermediate in the preparation of Roflumilast and related analogs, which is a selective PDE4 inhibitor, used in the treatment of severe chronic obstructive pulmonary disease (COPD).

References : Hatzelmann A. et al.: Pulm Pharmacol Ther., 23(4), 235-256, 2010; Rabe K. F. Br. J. Pharmacol., 163(1), 53-67, 2011; Hatzelmann A. et al.: J. Pharmacol Exp Ther., 297(1), 267-279, 2001; Richmond B. W. et al.: Nat. Commun. 7, 11240, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.