4-O-Des(difluoromethyl) roflumilast

SL-6470

4-O-Des(difluoromethyl) roflumilast, >98%

CAS No. : [475271-62-6]

IUPAC Name : 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
100MG	455.00		Back Order	Estimated to ship on 04 October 2026
250MG	655.00		Back Order	Estimated to ship on 04 October 2026
1G	1655.00		Back Order	Estimated to ship on 04 October 2026
5G	5555.00		Back Order	Estimated to ship on 04 October 2026

Applications : This is an impurity of Roflumilast, which is a selective phosphodiesterase-4 (PDE-4) inhibitor, used in the treatment of severe chronic obstructive pulmonary disease (COPD).

References : Hatzelmann A. et al.: Pulm Pharmacol Ther., 23(4), 235-256, 2010; Rabe K. F. Br. J. Pharmacol., 163(1), 53-67, 2011; Hatzelmann A. et al.: J. Pharmacol Exp Ther., 297(1), 267-279, 2001; Richmond B. W. et al.: Nat. Commun. 7, 11240, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.