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7-Bromo-2-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-6-methyl-3,4-dihydroisoquinolin-1(2H)-one

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SI-1620

7-Bromo-2-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-6-methyl-3,4-dihydroisoquinolin-1(2H)-one, 97%

CAS No. : [2115022-69-8]

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100MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C15H18BrNO3
Mol. Weight :
340.21
Appearance :
White solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of PF-06827443 related analogs, which is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM).

References : Davoren E. J. et al.: J. Med. Chem., 60(15), 6649-6663, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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