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8-Dechloro-10-chloro-desloratadine

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SL-4331

8-Dechloro-10-chloro-desloratadine, >98%

CAS No. : [1346600-61-0]

IUPAC Name : 10-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

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Chemical Properites
Mol. Formula :
C19H19ClN2
Mol. Weight :
310.83
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity or an analog of Desloratadine, which is a tricyclic H₁ antagonist that is used to treat allergies. It is an active metabolite of Loratadine.

References : Cardelus I. et al.: Eur. J. Pharmacol, 374(2), 249-254, 1999; Geha R. S. et al.: J. Allergy Clin Immunol, 107(4), 751-762, 2001; Schroeder J. T. et al.: Clin. Exp. Allergy, 31(9), 1369-1377, 2001; Anthes J. C. et al. Eur. J. Pharmacol, 449(3), 229-237, 2002; Howell G. et al.: BMC Pharmacol, 5, 13, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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