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(9R,12aR)-AZD-4747

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SI-8121

(9R,12aR)-AZD-4747, >98% (HPLC)

IUPAC Name : 1-((9R,12aR)-9-(2-Chloro-6-hydroxyphenyl)-10-fluoro-8-(prop-1-yn-1-yl)-3,4,12,12a-tetrahydro-6H-benzo[f]pyrazino[2,1-c][1,4]oxazepin-2(1H)-yl)prop-2-en-1-one

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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C24H22ClFN2O3
Mol. Weight :
440.9
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (9R,12aR)-AZD-4747 represents a diastereomeric form of AZD-4747, a BBB‑penetrant KRAS^G12C inhibitor. As part of the AZD-4747 stereochemical series, it is useful for investigating KRAS‑dependent cancers and structure–activity relationships.

References : Kettle J. G. et al.: J. Med. Chem., 66(13), 9147-9160, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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