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A-438079 hydrochloride

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SI-6526

A-438079 hydrochloride, >98% (HPLC)

CAS No. : [899431-18-6]

IUPAC Name : 3-((5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride

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Chemical Properites
Mol. Formula :
C13H9Cl2N5 • HCl
Mol. Weight :
342.61
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : A‑438079 hydrochloride selectively inhibits the P2X7 receptor with high potency (pIC50= 6.9), supporting its use in mechanistic studies of P2X7‑dependent cytokine release, inflammation, and pain pathways.

References : Mc Garaughty S. et al.: Neuroscience, 146(4), 1817-28, 2007; Mesuret G. et al.: CNS Neurosci. Ther., 20(6), 556-64, 2014; Marcellino D. et al.: J. Neural. Transm (Vienna)., 117(6), 681-7, 2010; Martins J. P. et al.: Br. J. Pharmacol., 165(1), 183-96, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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