A-740003

SI-6524

A-740003, >98% (HPLC)

CAS No. : [861393-28-4]

IUPAC Name : (E)-N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : A‑740003 selectively and competitively antagonizes the P2X7 receptor with nanomolar potency (IC₅₀ = 18 nM rat; 40 nM human), supporting its use in studies of P2X7‑dependent cytokine release, inflammation, and pain pathways.

References : Grol M. W. et al.: Am J. Physiol Endocrinol Metab., 302(5), E561-75, 2012; Kim J. E. et al.: J Neuroinflammation, 8, 62, 2011; Donnelly-Roberts D. L. et al.: Br J. Pharmacol., 157(7), 1203-14, 2009, . Epub 2009. Honore P. et al.: J. Pharmacol Exp Ther., 319(3), 1376-85, 2006, Epub 2006; Y. H. Gao. et al.: Purinergic Signal, 13(2), 215-225, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.