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A-867744

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SI-5669

A-867744, >98% (HPLC)

CAS No. : [1000279-69-5]

MDL No. : MFCD16495814

IUPAC Name : 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide

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Chemical Properites
Mol. Formula :
C20H19ClN2O3S
Mol. Weight :
402.89
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.

References : Malysz J. et. al.: J.Pharmacol.Exp.Ther. 330(1), 257-67, 2009; Faghih R. et. al.: J. Med. Chem. 28(10), 3377-84, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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