A₂A adenosine receptor antagonist

SI-7126

A₂A adenosine receptor antagonist, >98% (HPLC)

IUPAC Name : 1-Amino-N-(pyridin-2-ylmethyl)benzo[4,5]imidazo[1,2-a]pyrazine-3-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This a highly potent A₂A adenosine receptor antagonist with exceptional affinity (K_i = 0.08 nM). It demonstrates strong cAMP functional inhibition and T‑cell activation, showing markedly superior in vitro immunostimulatory activity compared with the clinical A₂AAR antagonist AZD-4635. In vivo, it significantly suppresses triple‑negative breast cancer (TNBC) growth by reversing the immunosuppressive tumor microenvironment, without severe toxicity at tested doses. It is a promising candidate for cancer immunotherapy research.

References : Liu S. et al.: J. Med. Chem., 65(13), 8933-8947, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.