A2AR-antagonist-1

SI-7296

A2AR-antagonist-1, >98% (HPLC)

CAS No. : [2922920-71-4]

IUPAC Name : 3-(2-Amino-6-(1-(3-(2-hydroxypropan-2-yl)benzyl)-2-oxo-1,2-dihydropyridin-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent A₂A receptor antagonist from an optimized pyridinone series, showing IC₅₀ = 29 nM, strong microsomal stability (t_1/2 = 86 min), and excellent oral bioavailability (F = 86%). It enhances T‑cell activation and delivers 56% tumor growth inhibition in the MC38 model, supporting its promise as a cancer immunotherapy candidate.

References : Zhu C. et al.: J. Med. Chem., 66(7), 4734-4754, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.