A56

SI-7331

A56, >98% (HPLC)

IUPAC Name : 5-((5-((2-Chloro-2'-fluoro-[1,1'-biphenyl]-3-yl)methoxy)-2-(((2-hydroxyethyl)amino)methyl)phenoxy)methyl)nicotinonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : A56 is a potent PD‑1/PD‑L1 inhibitor from a biphenyl‑benzylamine series, showing IC₅₀ = 2.4 ± 0.8 nM in HTRF assays and tight PD‑L1 binding (Kᴅ < 1 μM). X‑ray cocrystal data (3.5 Å) reveal a novel binding mode consistent with its high potency. In cell‑based systems, A56 strongly blocks hPD‑1/hPD‑L1 signaling, and in an hPD‑L1 MC38 humanized mouse model it achieves 55.2% tumor growth inhibition (50 mg/kg, oral). These properties position A56 as a promising clinical candidate for further PD‑1/PD‑L1‑directed cancer immunotherapy development.

References : Zhang H. et al.: J. Med. Chem., 66(15), 10579-10603, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.