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AAK1-IN-2

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SI-6976

AAK1-IN-2, >98% (HPLC)

CAS No. : [1802703-21-4]

IUPAC Name : (S)-2-(1-Amino-3-methylbutyl)-6-(pyridin-4-yl)quinoline-4-carbonitrile

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Chemical Properites
Mol. Formula :
C20H20N4
Mol. Weight :
316.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a potent, selective, and brain‑penetrant inhibitor of adaptor protein‑2 associated kinase 1 (AAK1), exhibiting an IC50 of 5.8 nM. It serves as a valuable tool molecule for investigating neuropathic pain mechanisms.

References : Hartz A. R. et al.: J. Med. Chem., 65(5), 4121-4155, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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