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Abemaciclib metabolite M20

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SI-5449

Abemaciclib metabolite M20, >98% (HPLC)

CAS No. : [2138499-06-4]

Synonyms : LSN-3106726

IUPAC Name : (6-(2-((5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-1H-benzo[d]imidazol-2-yl)methanol

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Chemical Properites
Mol. Formula :
C27H32F2N8O
Mol. Weight :
522.60
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a metabolite of Abemaciclib, which is a selective CDK4/6 inhibitor. Abemaciclib can be used for the treatment of breast cancer.

References : Ku B. M. et al.: Oncotarget., 7(12), 14803-13, 2016; Yadav V. et al.: Mol Cancer Ther., 13(10), 2253-63, 2014; Gelbert L. M. et al.: Invest New Drugs 32(5), 825-37, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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