ABT-737-d8

SI-6474

ABT-737-d₈, >98% (HPLC)

CAS No. : [1217686-68-4]

IUPAC Name : (R)-4-(4-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl-2-d₈)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : ABT‑737‑d₈ is a deuterated analog of the BH3 mimetic ABT‑737, retaining potent inhibition of Bcl‑2, Bcl‑xL, and Bcl‑w. It activates mitochondrial apoptosis through BCL‑2/BAX disruption and BAK‑dependent signaling, induces autophagy, and is valuable for AML‑related mechanistic and pharmacokinetic studies.

References : Russak E. M. et al.: Ann. Pharmacother., 53(2), 211-216, 2019; Konopleva M. et al.: Cancer Cell, 10(5), 375-88, 2006; Saleem A. et al.: Prostate., 72(12), 1374-81, 2012; Clerc P. et al.: PLoS One., 7(8), e42487, 2012; Cippà P. E. et al.: Transpl. Int., 24(7), 722-32, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.