ACK1/GCK inhibitor

SI-7956

ACK1/GCK inhibitor, >98% (HPLC)

IUPAC Name : 4-((3-(Dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a dual ACK1/GCK inhibitor with digit‑nanomolar potency that effectively blocks AKT/mTOR signaling and induces apoptosis, thereby suppressing the proliferation of mutant NRAS‑expressing AML cells. Its combined targeting of ACK1 and GCK provides a synergistic mechanism for disrupting oncogenic survival pathways, positioning it as a promising dual‑kinase therapeutic lead for NRAS‑driven acute myeloid leukemia.

References : Cho H. et al.: J. Med. Chem., 61(18), 8353-8373, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.