ACK1 inhibitor

SI-7949

ACK1 inhibitor, >98% (HPLC)

IUPAC Name : (R)-N-(3-(2-((2-Ethoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-8-((tetrahydrofuran-2-yl)methyl)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a highly potent and selective ACK1 inhibitor (IC₅₀ = 2.1 nM). It shows excellent kinome selectivity, sparing SRC, and robustly suppresses ACK1 and downstream AKT signaling in ASK120067‑resistant NSCLC cells. The compound demonstrates strong synergy with ASK120067 in vitro and exhibits reasonable PK with ~20% oral bioavailability, making it a promising lead for overcoming EGFR‑TKI resistance in NSCLC.

References : Li Q. et al.: J. Med. Chem., 66(10), 6905-6921, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.