ACK1 inhibitor

SI-7951

ACK1 inhibitor, >98% (HPLC)

IUPAC Name : N3-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-N6-(4-(piperazin-1-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a pyrazolo[3,4‑d]pyrimidine‑based small‑molecule ACK1 inhibitor engineered to block ACK1‑driven oncogenic signaling through a high‑affinity, kinase‑focused scaffold suitable for advancement as a targeted anticancer lead. It displays exceptional potency, with a biochemical K_i of 2 nM and cellular IC₅₀ of 10 nM, confirming strong target engagement and robust cellular activity consistent with high‑value ACK1 inhibition.

References : Li Q. et al.: J. Med. Chem., 66(10), 6905-6921, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.