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Acrizanib

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SI-6404

Acrizanib, >98% (HPLC)

CAS No. : [1229453-99-9]

Synonyms : LHA-510

IUPAC Name : N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide

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Chemical Properites
Mol. Formula :
C20H18F3N7O2
Mol. Weight :
445.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Acrizanib selectively inhibits VEGFR‑2 with low‑nanomolar potency (IC50 = 17.4 nM in BaF3‑VEGFR‑2 cells), making it a useful tool for probing VEGF‑mediated angiogenesis and related pathological processes.

References : Adams C. M. et al.: J. Med. Chem., 61(4), 1622-1635, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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