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ACY-738

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SL-1631

ACY-738, >98%

CAS No. : [1375465-91-0]

MDL No. : MFCD28347706

IUPAC Name : N-Hydroxy-2-((1-phenylcyclopropyl)amino)pyrimidine-5-carboxamide

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Chemical Properites
Mol. Formula :
C14H14N4O2
Mol. Weight :
270.29
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.

References : Jochems J. et al.: Neuropsychopharmacology. 39(2), 389-400, 2014: Regna N. L. et al.: Clin. Immunol., 162, 58-73, 2016; Br. J. Haematol., 162(4), 559-562, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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