ADAMTS‑5 inhibitor

SI-6235

ADAMTS‑5 inhibitor, >98% (HPLC)

IUPAC Name : (1S,2R,3R)-1-((8-Fluoro-1,2,3,4-tetrahydroimidazo[1,2-a:4,5-c']dipyridine)-2-sulfonamido)-2,3-dimethyl-2-phenylcyclopropane-1-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent, highly selective, and orally bioavailable aggrecanase inhibitor from the (1S,2R,3R)-2,3‑dimethyl‑2‑phenyl‑1‑sulfamidocyclopropanecarboxylate series. Its novel P1′ heterocycle-a 1,2,3,4‑tetrahydropyrido[3′,4′:4,5]imidazo[1,2‑a]pyridine ring-confers strong ADAMTS‑4/5 selectivity and excellent pharmacokinetic properties, outperforming classical hydroxamate inhibitors. It is a robust lead for osteoarthritis‑related aggrecanase research.

References : Shiozaki M. et al.: J. Med. Chem., 54(8), 2839-2863, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.