Adavosertib

SI-6765

Adavosertib, >98% (HPLC)

CAS No. : [955365-80-7]

Synonyms : AZD-1775; MK-1775

IUPAC Name : 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Adavosertib potently inhibits WEE1 with an IC₅₀ of 5.2 nM, leading to abrogation of the G₂/M checkpoint and increased replication stress. Its mechanism supports broad application in DNA‑damage‑driven cancer research.

References : Hirai H. et al.: Cancer Biol. Ther., 9(7), 514-22, 2010; Bridges K. A. et al.: Clin. Cancer Res., 17(17), 5638-48, 2011, Epub 2011; Rajeshkumar N. V. et al.: Clin. Cancer Res., 17(9), 2799-806, 2011, Epub 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.