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Adavosertib acid

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SI-6766

Adavosertib acid, >98% (HPLC)

CAS No. : [2714511-66-5]

Synonyms : AZD-1775 acid; MK-1775 acid

IUPAC Name : 2-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)acetic acid

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Chemical Properites
Mol. Formula :
C28H32N8O4
Mol. Weight :
544.62
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Adavosertib acid is a structurally modified form of AZD1775 incorporating a reactive acid moiety. This derivative is widely used as a ligand component in assembling PROTAC molecules designed to degrade WEE1.

References : Zhu S. et al.: Eur. J. Med. Chem., 243, 114786, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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