Advantame

SL-10129

Advantame, >98%

CAS No. : [714229-20-6]

IUPAC Name : (S)-3-((3-(3-Hydroxy-4-methoxyphenyl)propyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid hydrate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Advantame is an N-substituted derivative of aspartame and functions as a high-intensity, low-calorie sweetener. It can interact with plasma proteins and may induce hypotension, as well as inhibit the hERG K+ channel, leading to potential cardiotoxic effects. Advantame binds to the T1R2/T1R3 taste G protein-coupled receptor (GPCR), forming an oligomeric complex with NMBR that demonstrates biased heteromeric selectivity, resulting in marked sialidase activity in vitro. In prenatal developmental toxicity studies involving rabbits, Advantame has been associated with maternal gastrointestinal disturbances.

References : Skapinker E. et al.: Nutrients, 16(12), 1840, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.