Advantame acid

SL-10130

Advantame acid, >98%

CAS No. : [713524-95-9]

IUPAC Name : (S)-4-(((S)-1-Carboxy-2-phenylethyl)amino)-3-((3-(3-hydroxy-4-methoxyphenyl)propyl)amino)-4-oxobutanoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
10MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
25MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
50MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
100MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026

Applications : This is an impurity of Advantame, which is an N-substituted derivative of aspartame and functions as a high-intensity, low-calorie sweetener. It can interact with plasma proteins and may induce hypotension, as well as inhibit the hERG K+ channel, leading to potential cardiotoxic effects. Advantame binds to the T1R2/T1R3 taste G protein-coupled receptor (GPCR), forming an oligomeric complex with NMBR that demonstrates biased heteromeric selectivity, resulting in marked sialidase activity in vitro. In prenatal developmental toxicity studies involving rabbits, Advantame has been associated with maternal gastrointestinal disturbances.

References : Skapinker E. et al.: Nutrients, 16(12), 1840, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.