AEP-IN-3

SI-7468

AEP-IN-3, >98% (HPLC)

CAS No. : [2978521-26-3]

IUPAC Name : (2S,4R)-N-((S)-5-Amino-5-oxopent-1-yn-3-yl)-4-fluoro-1-(1-(4-(trifluoromethoxy)phenyl)cyclopropane-1-carbonyl)pyrrolidine-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : AEP‑IN‑3 is an orally active, potent, and brain‑penetrant AEP inhibitor with an IC₅₀ of 7.8 ± 0.9 nM. By selectively blocking asparagine endopeptidase, a protease implicated in pathogenic APP and tau cleavage, AEP‑IN‑3 serves as a valuable tool compound for Alzheimer’s disease research, enabling mechanistic studies and target validation in vivo.

References : Krummenacher D. et al.: J. Med. Chem., 66(24), 17026-17043, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.