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Afatinib bis-dimethylamino impurity

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Afatinib bis-dimethylamino impurity, >98%

CAS No. : [2414260-31-2]

IUPAC Name : N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide

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Chemical Properites
Mol. Formula :
C26H32ClFN6O3
Mol. Weight :
531.03
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Afatinib, which is an irreversible EGFR family inhibitor. Afatinib is used in the treatment of metastatic non-small cell lung cancer (NSCLC).

References : Ding X. H. et al.: Bioorg. Med. Chem. 23(9), 1895-1922, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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