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Afatinib impurity 12

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Afatinib impurity 12, >98%

CAS No. : [2121530-37-6]

IUPAC Name : (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide

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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C22H20ClFN4O4
Mol. Weight :
458.87
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Afatinib (Afatinib impurity 12), which is an irreversible EGFR family inhibitor. It is used to treat metastatic non-small cell lung cancer (NSCLC).

References : Li D. et al.: Oncogene 27(34), 4702-4711, 2008; Ferrarotto R. et al.: Expert Opin Investig Drugs 23(1), 135-43, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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