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Afatinib impurity 19

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SL-7153

Afatinib impurity 19, >98%

CAS No. : [1245555-42-3]

IUPAC Name : (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide

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Chemical Properites
Mol. Formula :
C21H21ClFN5O2
Mol. Weight :
429.88
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Afatinib (Afatinib impurity 19), which is an irreversible EGFR family inhibitor. It is used to treat metastatic non-small cell lung cancer (NSCLC).

References : Li D. et al.: Oncogene 27(34), 4702-4711, 2008; Ferrarotto R. et al.: Expert Opin Investig Drugs 23(1), 135-43, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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